Autism risk tied to mom's obesity during pregnancy

Autism is more likely to occur in children whose mothers were obese while pregnant, new research suggests.

The study, one of the first of its kind, involved about 1,000 California children, ages 2 to 5. Researchers affiliated with the UC Davis MIND Institute looked at their mothers' medical records and examined the association between obesity and autism. Women who were obese during pregnancy were about 67 percent more likely than normal-weight women to have autistic children, the study showed. Obese moms also faced double the risk of having children with other developmental delays.

Children born to obese women are more likely to be diagnosed with autism or related developmental delays than the children of slimmer mothers, according to a U.S. survey. 

The research, which appeared in Pediatrics, was looking for the impact on childrens' cognitive development from a variety of "metabolic conditions" in the mother, including high blood pressure or diabetes. The strongest links were found between obesity and autism-related disorders.

Although the study cannot prove that one condition causes the other, its authors caution that even the possibility is worrisome in the light of rising U.S. obesity rates.

Obesity isn't the only risk factor found for pregnant moms in the study. Researchers also looked at prevalence of gestational diabetes and found pregnant moms with diabetes had nearly 2 1/3 times the chance of having a child with developmental delays compared with healthy mothers. Although the proportion of diabetic mothers who had a child with autism was higher, the numbers did not reach statistical significance.

The study was published online in the April 9 issue of Pediatrics.

Among the children in the study with an autism spectrum disorder, 48 were born to mothers with Type 2 or gestational diabetes, 111 to mothers who were obese and 148 to mothers with any sort of metabolic condition, like high blood pressure.

For children with a developmental delay, 20 were born to mothers with Type 2 or gestational diabetes, 41 to mothers who were obese and 60 to a mother with any metabolic condition.

What explains the results? Researchers say the study does not indicate cause and effect - and further research must be done to confirm the results. But the authors theorize that obesity - generally about 35 pounds overweight - is linked with inflammation and sometimes elevated levels of blood sugar. Excess blood sugar and inflammation-related substances in a mother's blood may reach the fetus and damage the developing brain, study author Paula Krakowiak, an epidemiologist at the University of California, Davis, said.

Of those children, 517 had an autism spectrum disorder and 172 had developmental delays. For Krakowiak's study, the children's diagnoses were confirmed by a re-evaluation at the UC Davis MIND Institute.

Milder versions of autism, such as Asperger's syndrome, form a "spectrum" of autism-related disorders. In addition, impairments in any one of the autism-related cognitive skill areas are considered developmental delays.

On average, women face a 1 in 88 chance of having a child with autism, according to recent CDC figures. The new research suggests that obesity during pregnancy would increase that to a 1 in 53 chance, the authors said.

"Over a third of U.S. women in their childbearing years are obese and nearly one-tenth have gestational or type 2 diabetes during pregnancy," Krakowiak said in a written statement. "Our finding that these maternal conditions may be linked with neurodevelopmental problems in children raises concerns and therefore may have serious public-health implications."

Previous research has linked obesity during pregnancy with stillbirths, preterm births and some birth defects.

"There is a lot that is unknown and studies like these really help us figure out the questions that need to be answered," Gardener said.

But she warned that researchers are far from understanding what might create a link between obesity and autism.

U.S. autism rates have increased along with obesity rates, says Dr. Daniel Coury, chief of developmental and behavioral pediatrics at Nationwide Children's Hospital in Columbus, Ohio. He said the research suggests that may be more than a coincidence.

If mothers' obesity is truly related to autism, it would be only one of many contributing factors, said Coury, who was not involved in the study.

What other factors have been linked to autism? Genetics, mothers' illnesses and use of certain medicines during pregnancy are a few, according to the CDC.

Although the study looked at obesity in the mothers, it lacks information on women's diets and other habits during pregnancy that might have influenced fetal development.

The CDC has more on pregnancy complications, including obesity and gestational diabetes.